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125i labeled sdf 1a  (Revvity)


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    Structured Review

    Revvity 125i labeled sdf 1a
    125i Labeled Sdf 1a, supplied by Revvity, used in various techniques. Bioz Stars score: 90/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/125i+sdf+1a/MCP-1%2C%5B125I%5D-+labeled%2C+Bolton-Hunter+Labeled/us07777009-651-0-5
    Average 90 stars, based on 18 article reviews
    125i labeled sdf 1a - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Ligand Binding Assay:

    Article Title: Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Article Snippet: A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated.. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or the partial contribution of the two peptide bonds to the CXCR4 antagonism and anti-HIV activity was demonstrated.. FC131 and the analogues were shown to selectively inhibit SDF-1 binding to CXCR4, whereas no inhibition of binding of SDF-1 to CXCR7 was observed.

    Membrane:

    Article Title: Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Article Snippet: A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated.. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or the partial contribution of the two peptide bonds to the CXCR4 antagonism and anti-HIV activity was demonstrated.. FC131 and the analogues were shown to selectively inhibit SDF-1 binding to CXCR4, whereas no inhibition of binding of SDF-1 to CXCR7 was observed.

    Whole Genome Amplification:

    Article Title: Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Article Snippet: A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated.. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or the partial contribution of the two peptide bonds to the CXCR4 antagonism and anti-HIV activity was demonstrated.. FC131 and the analogues were shown to selectively inhibit SDF-1 binding to CXCR4, whereas no inhibition of binding of SDF-1 to CXCR7 was observed.

    Incubation:

    Article Title: Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Article Snippet: A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated.. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or the partial contribution of the two peptide bonds to the CXCR4 antagonism and anti-HIV activity was demonstrated.. FC131 and the analogues were shown to selectively inhibit SDF-1 binding to CXCR4, whereas no inhibition of binding of SDF-1 to CXCR7 was observed.

    Article Title: Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
    Article Snippet: The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV.. AMD3100 has been shown to be a CXCR4 receptor antagonist, and to block HIV infection of T-tropic, X4-using, virus in vitro and in vivo.. AMD3100 is an effective mobilizer of hematopoietic stem cells and is being investigated in clinical trials in multiple myeloma and non-Hodgkins lymphoma patients.

    Radioactivity:

    Article Title: Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Article Snippet: A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated.. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or the partial contribution of the two peptide bonds to the CXCR4 antagonism and anti-HIV activity was demonstrated.. FC131 and the analogues were shown to selectively inhibit SDF-1 binding to CXCR4, whereas no inhibition of binding of SDF-1 to CXCR7 was observed.

    Binding Assay:

    Article Title: Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
    Article Snippet: The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV.. AMD3100 has been shown to be a CXCR4 receptor antagonist, and to block HIV infection of T-tropic, X4-using, virus in vitro and in vivo.. AMD3100 is an effective mobilizer of hematopoietic stem cells and is being investigated in clinical trials in multiple myeloma and non-Hodgkins lymphoma patients.

    Concentration Assay:

    Article Title: Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
    Article Snippet: The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV.. AMD3100 has been shown to be a CXCR4 receptor antagonist, and to block HIV infection of T-tropic, X4-using, virus in vitro and in vivo.. AMD3100 is an effective mobilizer of hematopoietic stem cells and is being investigated in clinical trials in multiple myeloma and non-Hodgkins lymphoma patients.

    Activity Assay:

    Article Title: Optimal Inhibition of X4 HIV Isolates by the CXC Chemokine Stromal Cell-derived Factor 1α Requires Interaction with Cell Surface Heparan Sulfate Proteoglycans
    Article Snippet: .. 125I-SDF-1a (specific activity, 2200 Ci/mmol) was purchased from PerkinElmer Life Sciences. .. Fluorescent calcein-AM, Indo1/AM, and 5- (and 6)-{[(4-chloromethyl)benzoyl]-amino} tetramethylrhodamine (CMTMR) probes were obtained from Molecular Probes.



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